MyDogDNA – Merlins Testergebnisse

Genetische Vielfalt

Der Test misst die genetische Vielfalt des Hundes durch Durchsuchen von tausenden Stellen in seiner DNA. Die genetische Vielfalt stellt die Heterozygotie Ebene innerhalb der Rasse oder Zuchtgruppe dar. Jeder getestete Hund aktualisiert die Ansicht der genetischen Vielfalt der Rasse.
Silken Windsprites wurden zu wenige getestet, um einen Mittelwert für die Rasse zu erstellen. Merlins individueller Wert ist 32.3 %, der Mittelwert aller getesteten Hunde ist 34.6 %.

my-dog-dna-genetische-vielfalt-silken-windsprite-merlin

140 Mutationen wurden getestet, die bei anderen Rassen gefunden wurden. Keine Funde für diesen Hund.

Die Mehrheit der getesteten genetischen Störungen folgt entweder einem rezessiven (autosomal oder x-chromosomal) oder einem dominanten Vererbungsmodell. Die Ergebnisse werden als ‘frei’, ‘Träger’ oder ‘betroffen’ für rezessive und ‘frei’ oder ‘betroffen’ für dominant vererbte Störungen dargestellt.

Funktionsstörungen, die bei anderen Rassen gefunden wurden

Blood Disorders

FunktionsstörungErbgangErgebnis
Bleeding disorder due to P2RY12 defectAutosomal rezessivFrei
Canine Cyclic Neutropenia, Cyclic Hematopoiesis, Gray Collie Syndrome, (CN)Autosomal rezessivFrei
Canine Leucocyte Adhesion Deficiency (CLAD), type IIIAutosomal rezessivFrei
Factor IX Deficiency or Hemophilia B; Gly379Glu mutationAn das X-Chromosom gebunden, rezessivFrei
Factor IX Deficiency or Hemophilia B; mutation originally found in Airedale TerrierAn das X-Chromosom gebunden, rezessivFrei
Factor IX Deficiency or Hemophilia B; mutation originally found in German Wirehaired PointerAn das X-Chromosom gebunden, rezessivFrei
Factor IX Deficiency or Hemophilia B; mutation originally found in Lhasa ApsoAn das X-Chromosom gebunden, rezessivFrei
Factor VII DeficiencyAutosomal rezessivFrei
Factor VIII Deficiency or Hemophilia A; mutation originally found in BoxerAn das X-Chromosom gebunden, rezessivFrei
Factor VIII Deficiency or Hemophilia A; mutation originally found in German Shepherd DogAn das X-Chromosom gebunden, rezessivFrei
Factor VIII Deficiency or Hemophilia A; p.Cys548Tyr mutation originally found in German ShepherdAn das X-Chromosom gebunden, rezessivFrei
Glanzmann Thrombasthenia Type I, (GT); mutation originally found in Pyrenean Mountain DogAutosomal rezessiFrei
Hereditary Elliptocytosis.Frei
Hereditary Phosphofructokinase (PFK) DeficiencyAutosomal rezessivFrei
Macrothrombocytopenia; disease-linked SNP originally found in Norfolk and Cairn TerrierAutosomal rezessivFrei
May-Hegglin Anomaly (MHA)Autosomal dominantFrei
Prekallikrein DeficiencyAutosomal rezessivFrei
Pyruvate Kinase Deficiency; mutation originally found in BasenjiAutosomal rezessivFrei
Pyruvate Kinase Deficiency; mutation originally found in BeagleAutosomal rezessivFrei
Pyruvate Kinase Deficiency; mutation originally found in Labrador RetrieverAutosomal rezessivFrei
Pyruvate Kinase Deficiency; mutation originally found in PugAutosomal rezessivFrei
Pyruvate Kinase Deficiency; mutation originally found in West Highland White TerrierAutosomal rezessivFrei
Thrombopathia; mutation originally found in Basset HoundAutosomal rezessivFrei
Thrombopathia; mutation originally found in Eskimo SpitzAutosomal rezessivFrei
Thrombopathia; mutation originally found in LandseerAutosomal rezessivFrei
Trapped Neutrophil Syndrome, (TNS)Autosomal rezessivFrei
Von Willebrand’s Disease (vWD) Type IIAutosomal rezessivFrei

Dermal Disorders

Funktionsstörung ErbgangErgebnis
Dystrophic Epidermolysis BullosaAutosomal rezessivFrei
Epidermolytic HyperkeratosisAutosomal rezessivFrei
Hereditary Footpad Hyperkeratosis, (HFH)Autosomal rezessivFrei
Lamellar Ichthyosis, (LI)Autosomal rezessivFrei
Musladin-Lueke syndrome, (MLS)Autosomal rezessivFrei
X-Linked Ectodermal Dysplasia, (XHED)An das X-Chromosom gebunden, rezessivFrei

Endocrine Disorders

FunktionsstörungErbgangErgebnis
Congenital Hypothyroidism; mutation originally found in Toy Fox- and Rat TerrierAutosomal rezessivFrei

Immunologic Disorders

FunktionsstörungErbgangErgebnis
Autosomal Recessive Severe Combined Immunodeficiency, (ARSCID)Autosomal rezessivFrei
Complement 3 (C3) DeficiencyAutosomal rezessivFrei
Severe Combined Immunodeficiency in Frisian Water Dogs, (SCID)Autosomal rezessivFrei
X-linked Severe Combined Immunodeficiency (XSCID); mutation originally found in Basset HoundAn das X-Chromosom gebunden, rezessivFrei
X-linked Severe Combined Immunodeficiency (XSCID); mutation originally found in Cardigan Welsh CorgiAn das X-Chromosom gebunden, rezessivFrei

Metabolic Disorders

FunktionsstörungErbgang Ergebnis
Glycogen Storage Disease Type Ia, (GSD Ia)Autosomal rezessivFrei
Glycogen Storage Disease Type II or Pompe’s Disease, (GSD II)Autosomal rezessivFrei
Glycogen Storage Disease Type IIIa, (GSD IIIa)Autosomal rezessivFrei
Hypocatalasia or AcatalasemiaAutosomal rezessivFrei
Intestinal Cobalamin Malabsorption or Imerslund-Gräsbeck Syndrome, (IGS); mutation originally found in BeagleAutosomal rezessivFrei
Intestinal Cobalamin Malabsorption or Imerslund-Gräsbeck Syndrome, (IGS); mutation originally found in Border CollieAutosomal rezessivFrei
Mucopolysaccharidosis Type 3A, (MPS IIIA); mutation originally found in DachshundAutosomal rezessivFrei
Mucopolysaccharidosis Type 3A, (MPS IIIA); mutation originally found in New Zealand HuntawayAutosomal rezessivFrei
Mucopolysaccharidosis Type VII, (MPS VII); mutation originally found in Brazilian TerrierAutosomal rezessivFrei
Mucopolysaccharidosis Type VII, (MPS VII); mutation originally found in German ShepherdAutosomal rezessivFrei
Pyruvate Dehydrogenase Phosphatase 1 (PDP1) DeficiencyAutosomal rezessivFrei

Muscular Disorders

FunktionsstörungErbgangErgebnis
Cavalier King Charles Spaniel Muscular Dystrophy (CKCS-MD)An das X-Chromosom gebunden, rezessivFrei
Centronuclear Myopathy, (CNM); mutation originally found in Great DaneAutosomal rezessivFrei
Centronuclear Myopathy, (CNM); mutation originally found in Labrador RetrieverAutosomal rezessivFrei
Duchenne or Dystrophin Muscular Dystrophy, (DMD)An das X-Chromosom gebunden, rezessivFrei
Muscular Hypertrophy (Double Muscling)Autosomal rezessivFrei
MyotoniaAutosomal rezessivFrei
Myotonia Congenita; mutation originally found in Australian Cattle DogAutosomal rezessivFrei
X-Linked Myotubular MyopathyAn das X-Chromosom gebunden, rezessivFrei
Adult-Onset Neuronal Ceroid Lipofuscinosis, (Adult-onset NCL), mutation originally found in Tibetan terrierAutosomal rezessivFrei
Alaskan Husky Encephalopathy, (AHE)Autosomal rezessivFrei
Bandera’s Neonatal Ataxia, (BNAt)Autosomal rezessivFrei
Benign Familial Juvenile Epilepsy or Remitting Focal EpilepsyAutosomal rezessivFrei
Early-Onset Progressive Polyneuropathy; mutation originally found in Alaskan MalamuteAutosomal rezessivFrei
Early-Onset Progressive Polyneuropathy; mutation originally found in GreyhoundAutosomal rezessivFrei
Fetal Onset Neuroaxonal Dystrophy, (FNAD)Autosomal rezessivFrei
Hereditary Ataxia or Cerebellar Ataxia; mutation originally found in Old English Sheepdog and Gordon SetterAutosomal rezessivFrei
Hyperekplexia or Startle DiseaseAutosomal rezessivFrei
Hypomyelination in WeimaranersAutosomal rezessivFrei
L-2-Hydroxyglutaric aciduria, (L2HGA); mutation 1 originally found in Staffordshire Bull TerrierAutosomal rezessivFrei
Lagotto Storage Disease, (LSD)Autosomal rezessivFrei
Neonatal Cerebellar Cortical Degeneration or Cerebellar Abiotrophy, (NCCD)Autosomal rezessivFrei
Neonatal Encephalopathy with Seizures, (NEWS)Autosomal rezessivFrei
Neuronal Ceroid Lipofuscinosis 8, (NCL8)Autosomal rezessivFrei
Neuronal Ceroid Lipofuscinosis 8, (NCL8); rare variantAutosomal rezessivFrei
Neuronal Ceroid Lipofuscinosis Type 1, (NCL1)Autosomal rezessivFrei
Neuronal Ceroid Lipofuscinosis Type 10, (NCL10)Autosomal rezessivFrei
Progressive early-onset cerebellar ataxia; mutation originally found in Finnish HoundAutosomal rezessivKein Ergebnis
Spinal DysraphismAutosomal rezessivFrei
Spinocerebellar Ataxia with Myokymia and/or Seizures (SCA)Autosomal rezessivFrei
Spinocerebellar Ataxia/ Late-Onset Ataxia (SCA, LOA)Autosomal rezessivFrei
X-Linked Tremors; mutation originally found in English Springer SpanielAn das X-Chromosom gebunden, rezessivFrei

Neuromuscular Disorders

FunktionsstörungErbgangErgebnis
Congenital Myasthenic Syndrome, (CMS)Autosomal rezessivFrei
Episodic Falling, (EF)Autosomal rezessivFrei
Globoid Cell Leukodystrophy or Krabbe’s Disease, (GLD); mutation originally found in Irish SetterAutosomal rezessivFrei
Globoid Cell Leukodystrophy or Krabbe’s Disease, (GLD); Terrier mutationAutosomal rezessivFrei
GM1 Gangliosidosis; mutation originally found in Alaskan HuskyAutosomal rezessivFrei
GM1 Gangliosidosis; mutation originally found in Portuguese Water DogAutosomal rezessivFrei
GM1 Gangliosidosis; mutation originally found in Shiba DogAutosomal rezessivFrei
GM2 Gangliosidosis, mutation originally found in Japanese ChinAutosomal rezessivFrei
GM2 Gangliosidosis; mutation originally found in Toy PoodleAutosomal rezessivFrei

Ocular Disorders

FunktionsstörungErbgangErgebnis
Canine Multifocal Retinopathy 1, (CMR1); Mastiff-related breeds mutationAutosomal rezessivFrei
Canine Multifocal Retinopathy 2, (CMR2); mutation originally found in Coton de TulearAutosomal rezessivFrei
Canine Multifocal Retinopathy 3, (CMR3); mutation originally found in Lapponian HerderAutosomal rezessivFrei
Cone Degeneration, (CD) or AchromatopsiaAutosomal rezessivFrei
Cone Degeneration, (CD) or Achromatopsia; mutation originally found in German Shorthaired PointerAutosomal rezessivFrei
Cone-Rod Dystrophy 1, (crd1); mutation originally found in American Staffordshire TerrierAutosomal rezessivFrei
Cone-Rod Dystrophy 2, (crd2); mutation originally found in Pit Bull TerrierAutosomal rezessivFrei
Cone-Rod Dystrophy, (cord1-PRA / crd4)Autosomal rezessiv mit unvollständiger Ausprägung
Frei
Cone-Rod Dystrophy, Standard Wirehaired Dachshund, (crd SWD)Autosomal rezessivFrei
Dominant Progressive Retinal Atrophy, (DPRA)Autosomal dominantFrei
Early Retinal Degeneration, (erd); mutation originally found in Norwegian ElkhoundAutosomal rezessivFrei
Generalized Progressive Retinal AtrophyAutosomal rezessivFrei
Glaucoma in the Norwegian ElkhoundAutosomal rezessivFrei
Golden Retriever Progressive Retinal Atrophy 1, (GR_PRA 1)Autosomal rezessivFrei
Primary Hereditary Cataract (PHC); mutation originally found in Australian ShepherdAutosomal dominant mit unvollständiger Ausprägung
Frei
Primary Lens Luxation, (PLL)Autosomal rezessivFrei
Primary Open Angle Glaucoma, (POAG); mutation originally found in BeagleAutosomal rezessivFrei
Progressive Retinal Atrophy, (PAP1_PRA); mutation originally found in Papillon and PhaleneAutosomal rezessivFrei
Progressive Retinal Atrophy, (PRA); mutation originally found in BasenjiAutosomal rezessivFrei
Rod-Cone Dysplasia 1, (rcd1); mutation originally found in Irish SetterAutosomal rezessivFrei
Rod-Cone Dysplasia 1a, (rdc1a); mutation originally found in SloughiAutosomal rezessivFrei
Rod-Cone Dysplasia 3, (rcd3)Autosomal rezessivFrei
X-Linked Progressive Retinal Atrophy 1, (XLPRA1)An das X-Chromosom gebunden, rezessivFrei
X-Linked Progressive Retinal Atrophy 2, (XLPRA2)An das X-Chromosom gebunden, rezessivFrei

Other Disorders

FunktionsstörungErbgangErgebnis
Amelogenesis Imperfecta, (AI)Autosomal rezessivFrei
Congenital Keratoconjunctivitis Sicca and Ichthyosiform Dermatosis, (CKCSID)Autosomal rezessivFrei
Narcolepsy; mutation originally found in DachshundsAutosomal rezessivFrei
Narcolepsy; mutation originally found in Doberman PinscherAutosomal rezessivFrei
Narcolepsy; mutation originally found in Labrador RetrieverAutosomal rezessivFrei
Persistent Müllerian Duct Syndrome, (PMDS); mutation originally found in Miniature SchnauzerAutosomal rezessivFrei
Primary Ciliary Dyskinesia, (PCD)Autosomal rezessivFrei

Pharmacogenetics

FunktionsstörungErbgangErgebnis
Malignant Hyperthermia (MH)Autosomal dominantFrei

Renal Disorders

FunktionsstörungErbgangErgebnis
Cystinuria Type I-A; mutation originally found in Newfoundland DogAutosomal rezessivFrei
Cystinuria, Type II-A; mutation originally found in Australian Cattle DogAutosomal dominantFrei
Cystinuria, Type II-B; mutation originally found in Miniature PinscherAutosomal dominantFrei
Hyperuricosuria, (HUU)Autosomal rezessivFrei
Polycystic Kidney Disease in Bull Terriers, (BTPKD)Autosomal dominantFrei
Primary Hyperoxaluria, (PH); mutation originally found in Coton de TulearAutosomal rezessivFrei
Renal Cystadenocarcinoma and Nodular Dermatofibrosis, (RCND)Autosomal dominantFrei
X-Linked Hereditary Nephropathy, (XLHN)An das X-Chromosom gebunden, rezessivFrei

Skeletal Disorders

FunktionsstörungErbgangErgebnis
Chondrodysplasia; mutation originally found in Norwegian Elkhound and Karelian Bear DogAutosomal rezessivFrei
Cleft Palate; Cleft Lip and Palate with Syndactyly; DLX6 gene mutation originally found in Nova Scotia Duck Tolling RetrieverAutosomal rezessivFrei
Craniomandibular Osteopathy, (CMO)Autosomal dominant mit unvollständiger Ausprägung
Frei
Hereditary Vitamin D-Resistant Rickets, (HVDRR)Autosomal rezessivFrei
Oculoskeletal Dysplasia 2 or Dwarfism-Retinal Dysplasia 2Autosomal rezessivFrei
Osteochondrodysplasia in Miniature PoodlesAutosomal rezessivFrei
Osteogenesis Imperfecta, (OI) found in the Beagle.Frei
Osteogenesis Imperfecta, (OI) or Brittle Bone Disease; mutation originally found in DachshundAutosomal rezessivFrei
Skeletal Dysplasia 2, (SD2)Autosomal rezessivFrei

Merkmale

Fellfarben

Merkmal / EigenschaftGenotyp
Color Locus E – Extensions
Beschreibung: The dog is likely to have a dark mask.
Em/E
Color Locus E (MC1R gene): Recessive Red, Yellow, Cream (e allele)
Beschreibung: Dogs with this genotype do not carry any copies of the recessive e allele, instead they carry two copies of a genetic variant that is typically associated with dark coat colours, like black, brown or blue, but also with other colours. As this test evaluates the presence of a general colour modifying element, carrying this genotype means that effect of other colour modifying loci can be expressed and manifested in the dog’s appearance.
C/C
Color Locus E (MC1R gene): Dark Mask (Em allele)
Beschreibung: Dogs with this genotype have one copy of the Em allele typically associated with a dark facial mask.
A/G
Color Locus E (MC1R gene): Grizzle, Domino (Eg allele)
Beschreibung: Dogs with this genotype do not carry any copies of the EG allele, the genetic variant associated with grizzle or domino coat colour.
G/G
Color Locus B – Brown
Beschreibung: The dog doesn’t have any of the tested b alleles causing brown color.
B/B || B/bd || bd/bd
Color Locus B (TYRP1 gene): brown, liver (bc allele)
Beschreibung: Dogs with this genotype do not carry any copies of the bc allele typically associated with brown coat color.
T/T
Color Locus B (TYRP1 gene): brown, liver (bs allele)
Beschreibung: Dogs with this genotype do not carry any copies of the tested bs allele typically associated with brown coat color.
C/C
Color Locus K – Dominant Black
Beschreibung: The dog is likely to express the coat color defined by the color locus A.
ky/ky
Color Locus K (CBD103 gene): Dominant Black (KB allele)
Beschreibung: Dogs with this genotype have no copies of the KB allele associated with solid black coat color.
-/-
Color Locus A – Agouti
Beschreibung: The dog is genetically sable. The dog carries tan points or saddle tan color.
ay/at
Color locus A (ASIP gene): Fawn, sable (ay-allele)
Beschreibung: Dogs with this genotype have one copy of the ay allele associated with fawn or sable coat color.
G/T
Color Locus A (ASIP gene): Black and Tan, Saddle Tan (at allele)
Beschreibung: Dogs with this genotype have one copy of the at allele associated with black and tan or saddle tan color.
C/T
Color Locus A (ASIP gene): Recessive Black (a allele)
Beschreibung: Dogs with this genotype don’t carry the a allele associated with recessive black coat color.
G/G
Color Locus S – Piebald or extreme white spotting
Beschreibung: The dog is likely to have solid coat color or few white spots in its coat.
S/sp
Color Locus S: Piebald or extreme white spotting
Beschreibung: Dogs with this genotype have one copy of the allele typically associated with piebald spotting or extreme white spotting.
-/INS
Color Locus H – Harlequin
Beschreibung: The dog doesn’t have harlequin pattern.
h/h
Color Locus H (PSMB7 gene): Harlequin (H allele)
Beschreibung: Dogs with this genotype don’t carry the H allele associated with harlequin patterning.
T/T
Color Pattern – Saddle Tan
Beschreibung: The dog may have saddle tan pattern if it has also tan point genotype at the A locus.
-/dup

Fellart

Merkmal / EigenschaftGenotyp
Improper Coat in Portuguese Water Dogs (marker test)
Beschreibung: The dog is not genetically likely to express furnishings.
GG/TC
Furnishings (moustache and eyebrows) / Improper Coat in Portuguese Water Dogs, variant chr13:11676852
Beschreibung: The dog does not have the variant associated with furnishings.
G/G
Coat Furnishings (moustache and eyebrows) / Improper Coat in Portuguese Water Dogs, variant chr13:11659792
Beschreibung: Dogs with this genotype carry one copy of the genetic variant strongly associated with furnishings and one copy of the genetic variant associated with the wild type phenotype (improper coat in Portuguese Water Dog). The T-allele shows strong correlation with furnishings and dogs with this genotype often express said trait. The heterozygous genotype (C/T) is common in breeds like Parson Russel Terrier and Kromfohrländer.
C/T
Coat length
Beschreibung: The dog carries two copies of the genetic variant typically associated with a long-haired coat. Dogs with this genotype typically have long coat.
T/T
Curly coatKein Ergebnis

Morphology

Merkmal / EigenschaftGenotyp
Bobtail
Beschreibung: The dog does not carry any copy of the bobtail mutation. It therefore likely has a long-tailed phenotype.
C/C
Body mass, insulin-like growth factor 1 (IGF1) gene variant
Beschreibung: The dog is heterozygous for this variant. This means that it carries one copy of the genetic variant typically associated with small body mass and one copy typically associated with large body mass. This genotype is often observed e.g. in Shetland Sheepdog, Border Collie and Welsh Corgi.
A/G
Ear erectness (pricked ears versus floppy ears), variant chr10:11072007
Beschreibung: The dog is homozygous and carries two copies of a genetic variant typically associated with pricked ears. This genotype is common in breeds like Finnish Spitz, German Shepherd, Samoyed, Terriers and in Collie-related breeds.
T/T
Snout/skull length (shortened head versus elongated head), bone morphogenetic protein 3 (BMP3) gene variant
Beschreibung: Your dog is homozygous for the genetic variant typically found in breeds with an elongated head (e.g. Saluki, Collie, Irish Wolfhound).
C/C
Tiny size, insulin-like growth factor 1 receptor (IGF1R) gene variant
Beschreibung: Your dog is homozygous for a genetic variant typically found in larger-sized breeds (height at the withers > 25.4 cm (10 inches)).
G/G